Male Silhouette

David Hunt

Start Year: 2012
Starting Institution: Janelia Farms
Current Institution: Janelia Farms
Project Title: Characterization of cellular bistability in CA3 pyramidal neurons

The hippocampus is a region of the brain critical for the cognitive functions of learning and memory. Pyramidal neurons in the CA3 region of the hippocampus are known to be essential for spatial information processing and memory. Understanding the biophysical mechanisms that underlie the computations carried out by this cell type is critical to understanding how CA3 cells support the cognitive functions mediated by the hippocampus. The property of bistability, or the capacity of a cell to maintain two distinct, yet stable states of firing output is a prominent mode by which cells process information. My research aims to understand the property of bistability in CA3 pyramidal neurons of the hippocampus. Through this investigation I hope to gain a greater insight into the biophysical mechanisms of individual cells that underlie spatial information processing at the network level.