Experience dependent plasticity is prevalent within the dorsomedial shell inferior colliculus (IC), and thus is hypothesized to be a critical point for synaptic plasticity within the auditory system. Surprisingly, the synaptic basis of this phenomenon has not been formally examined. Therefore, short-term plasticity will be investigated using paired whole-cell slice electrophysiology recordings in the mouse dorsomedial IC. With paired recordings, the connectivity of the IC microcircuit can also be determined. The prevalence of connected neuronal pairs will illustrate the extent to which plasticity can be relayed in the local circuit. These outcomes will be furthered by biocytin reconstructions of the recorded neurons to examine proximity of connected neurons, their morphology and their orientation within the frequency organization of the IC. These results will provide direct evidence for IC neurons’ ability to undergo synaptic plasticity, a feature that is predicted by years of work, and inform our understanding of the IC microcircuitry, which has implications for local network computations.