Harris, Nathan

Temperature induced plasticity of motoneuron transcriptome and set-point excitability.

  • University of California, San Francisco
Harris, Nathan
The acute temperature dependence of many biological processes, including neuronal excitability, have been described. But much less is known about how the nervous system responds to long-term changes in temperature. As a grass fellow I will manipulate temperature during the development of Drosophila melanogaster, which is likely to be a critical period for the establishment of a neuron’s molecular and functional identity, and investigate the resulting effects on motoneuron excitability, robustness to acute temperature change, and transcriptome. I will then repeat these experiments in progeny from mothers undergoing reproductive diapause, a naturalistic response to extreme temperature. These experiments will help to explain the basic but elusive question of how set-point excitability is established during development, and how a simple environmental perturbation affects the development and function of the nervous system.

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